- Susan Mayer is a forty something divorcee living with her 14-year-old daughter, Julie. Her romantic heart always has her looking for her next great love. Writing and illustrating children's books has kept her around Wisteria Lane most days making it easy for her to keep an eye on neighborhood beau, Mike Delfino, her occasional boyfriend.
She and her wise-beyond-years daughter have a tell all relationship often resulting in a parental role reversal. Susan often consults with Julie on important decisions like which dress was sexier for her first date with Mike and how to best stalk him after he became a presumed killer. Inevitably, Julie was always the one there to pick up the pieces, a tradition which began when Susan's adulterous ex-husband, Karl, walked out on them.
Susan's notoriously clumsy escapades have resulted in accidental arson, embarrassing public nudity and an unsightly encounter with a mechanical bull. Unfortunately her magnetic charm tends to attract trouble usually involving her secretive neighbor, Paul Young. She found herself knee-deep in a mystery surrounding her late friend Mary Alice Young's death involving a cryptic blackmail note, a dead woman's journal and a baby named Dana who may in fact be Mike's child.
- Lynette Scavo was once best known as a savvy career woman. In the work force she was an over-achiever who could accomplish any task, but those days came to an end when she and her husband, Tom, decided to have children. She gave up the working world and within six years had twin boys, a five year old son and a baby girl. Soon, she gained a new reputation as the mother of quite possibly the most unruly children ever born.
In her efforts to tame her children and keep up with her domestic responsibilities, Lynette developed an addiction to her children's ADD medication that she eventually overcame with the help from the women of Wisteria Lane.
While Lynette's intentions are usually genuine, her actions often are not. Her need to actively meddle in the lives of others for the greater good led her to tank her own husband's promotion in order to preserve his time with their family. Unfortunately for Lynette, Tom found out about her subterfuge, but decided that she was right. He needed more time with the children. With that he quit his job and resolved to become a stay-at-home dad sending his wife back out into the professional arena with a seven year gap in her resume.
- Bree Van de Kamp is a searing, uptight perfectionist. Her strong resolve and proper demeanor have caused tension in her marriage and home-life. As a mother of two teenagers, her icy cool nerves were often tested. She struggled to rein in her rebellious, and at times soulless son, Andrew, and fought to give her self-absorbed daughter, Danielle, a proper perspective on life.
During a routine meeting with the neighborhood call-girl, her husband Rex suffered a heart attack, thus shining a light on his dark secrets. Bree reluctantly cared for him during his recovery after her children's insistence. He marriage was further troubled when she began dating the local pharmacist, George Williams, much to her husband's dismay. Rex took matters into his own hands when he went to ward off George, only inciting his jealousy which led him to begin tampering with Rex's heart medication. Bree was eventually widowed when after months of poisoning by their pharmacist, Rex's heart gave way.
Despite all this, her "perfect housewife" routine remained nearly unshaken during the past year. She was able to keep up appearances at the country club, find time to bake muffins for her incarcerated arch nemesis, Maisy Gibbons and somehow maintain her perfectly quaffed flip.
- Gabrielle Solis, the youngest of the housewives on Wisteria Lane, spent her early days climbing out of a desperate situation to become a glamorous runway model in New York where she met her husband, Carlos. She gave up her exciting life and married him on the spot, knowing that he would be able to provide everything she could ever want: an exquisite home, jet-setting vacations and a bottomless bank account. It was only after moving to suburbia that Gabrielle realized that perhaps she wanted all the wrong things.
With Carlos' long days now spent at the office, Gabrielle quickly became bored with her new life and began an illicit affair with her stunning underage gardener, John. She struggled to keep her affair under wraps and after several close calls was seemingly let off the hook when her husband was arrested. During this time she was forced to take a variety of odd jobs which often put her in uncomfortable and humiliating positions, such as showcasing mattresses for Valentine's Day and displaying Buicks at the local mall while having her dress caught in the revolving display.
Gabrielle's life was further undermined by her husband's desire to have children spurred on by the untimely death of his mother. He successfully tampered with his wife's birth control and she became pregnant, but with who's child? His or the gardener's?
News of the affair finally came out, but at the worst time. Carlos, already under house arrest for importing slave labor and now up on charges for assault and battery, flew into a jealous rage during his trial upon discovery of the affair only incriminating himself further and possibly sending him away for no less than 8 years.

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